Pneumococcal serotypes in carrier children prior to the introduction of anti-pneumococcal vaccines in Peru

Authors

  • Erik H. Mercado Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. Biólogo.
  • Martha Egoavil Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. médico cirujano.
  • Sara G. Horna Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. tecnóloga médico.
  • Nancy Torres Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • Ricardo Velásquez Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • María E. Castillo Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. Instituto Nacional de Salud del Niño. Lima, Perú. médico infectólogo pediatra.
  • Eduardo Chaparro Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. médico infectólogo pediatra.
  • Roger Hernández Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. Hospital Nacional Cayetano Heredia. Lima, Perú. médico infectólogo pediatra.
  • Wilda Silva Hospital Nacional Edgardo Rebagliati Martins. Lima, Perú. médico infectólogo pediatra.
  • Francisco E. Campos Hospital Nacional Docente Madre-Niño San Bartolomé. Lima, Perú. médico infectólogo pediatra.
  • Andrés Sáenz Hospital Nacional Daniel A. Carrión. Lima, Perú. médico infectólogo pediatra.
  • Félix Hidalgo Hospital Regional del Cusco. Cusco, Perú. médico infectólogo pediatra.
  • Carolina Letona Centro de Salud de Wanchaq. Cusco, Perú. médico infectólogo pediatra,
  • Ángel G. Valencia Hospital Guillermo Díaz de la Vega, Abancay. Apurímac, Perú. médico infectólogo pediatra.
  • Rosario Cerpa Hospital EsSalud de Yanahuara. Arequipa, Perú. médico infectólogo pediatra.
  • Bernardo López-de-Romaña Policlínico Metropolitano de Arequipa. Arequipa, Perú. médico infectólogo pediatra.
  • Jackeline Pando Clinical Lecturer, Department of Paediatrics and Child Health, University College Cork. Irlanda. médico infectólogo pediatra.
  • Berenice Torres Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • Fiorella Castillo Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • Andrea Calle Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • Synthia Rabanal Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.
  • Theresa J. Ochoa Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia. Lima, Perú. estudiante de Medicina.

DOI:

https://doi.org/10.17843/rpmesp.2012.291.308

Keywords:

Streptococcus pneumoniae, Carriage, Serotyping, Child, Peru

Abstract

Objectives. To determine the carriage rate and serotype distribution of Streptococcus pneumoniae in the nasopharynx of healthy children younger than 2 years prior to the universal use of the pneumococcal conjugate vaccines in Peru. Materials and methods. Between 2007 and 2009 we collected nasopharyngeal swab samples from 2,123 healthy children aged 2 to 24 months in the vaccination and healthy children consultation offices of pediatric hospitals and health centers in 7 cities in Peru: on the coast (Lima, Piura), highlands (Cusco, Abancay, Arequipa and Huancayo) and amazon basin (Iquitos). The pneumococcal strains were isolated and identified at the central laboratory of the project in Lima, and serotyped by Quellung reaction in the pneumococcal reference laboratory at the Center for Diseases Control and Prevention (CDC). Results. We found 27% (573/2123) of pneumococcal nasopharyngeal healthy carrier children. Among the 526 analyzed strains, we found 42 serotypes; the most common were: 19f (18.1%), 6B (14.3%); 23f (8.9%) and 14 (6.5%). Conclusions. The distribution of vaccine serotypes in the analyzed strains was of 50% for the serotypes present in the seven-valent vaccine, 50.2% for the serotypes present in the ten-valent vaccine and 57.2% for those present in the thirteen-valent vaccine.

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Published

2014-01-29

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Section

Research Articles

How to Cite

1.
Mercado EH, Egoavil M, Horna SG, Torres N, Velásquez R, Castillo ME, et al. Pneumococcal serotypes in carrier children prior to the introduction of anti-pneumococcal vaccines in Peru. Rev Peru Med Exp Salud Publica [Internet]. 2014 Jan. 29 [cited 2024 Jun. 19];29(1). Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/308

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