Clinical-epidemiological analysis of HDL2 and HDL3 subfractions in adults from Maracaibo city, Venezuela

Authors

  • Sergia Linares Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. magíster en Nutrición; magíster en Metabolismo Humano, doctor en Ciencias Médicas https://orcid.org/0000-0003-0159-0818
  • Valmore Bermúdez Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia. magíster en Metabolismo Humano, doctor en Ciencias Médicas https://orcid.org/0000-0003-1880-8887
  • Juan Salazar Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. médico cirujano; especialista en Medicina Interna https://orcid.org/0000-0003-4211-528X
  • Manuel Nava Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. estudiante de Medicina Humana https://orcid.org/0000-0001-9769-1693
  • Ángel Ortega Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. estudiante de Medicina Humana https://orcid.org/0000-0002-7180-4765
  • Luis Olivar Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. estudiante de Medicina Humana https://orcid.org/0000-0002-9325-6376
  • María Calvo Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. estudiante de Medicina Humana https://orcid.org/0000-0002-9569-2796
  • María Sofía Martínez Centro de Investigaciones Endocrino-Metabólicas «Dr. Félix Gómez», Escuela de Medicina, Universidad del Zulia, Maracaibo, Venezuela. médico cirujano https://orcid.org/0000-0002-3419-0960
  • Alex Morales-Carrasco Universidad Técnica de Ambato, Ambato, Ecuador. médico cirujano https://orcid.org/0000-0002-7991-0685
  • Maricarmen Chacín Universidad Simón Bolívar, Facultad de Ciencias de la Salud, Barranquilla, Colombia. magíster en Dermatología https://orcid.org/0000-0002-5208-9401
  • Joselyn Rojas Pulmonary and Critical Care Medicine Department, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, Estados Unidos. magíster en Inmunología. https://orcid.org/0000-0003-4994-075X

DOI:

https://doi.org/10.17843/rpmesp.2020.373.4787

Keywords:

Lipoproteins, HDL3, HDL2, Cholesterol, HDL, Risk Factors, Epidemiology

Abstract

Objective: To carry out a clinical-epidemiological analysis of high-density lipoprotein cholesterol subfractions (HDL-C) in adults from Maracaibo, Venezuela. Materials and methods: A descriptive and cross-sectional study of the database from the Metbolic Syndrome Prevalence in Maracaibo Study was carried out. HDL3 and HDL2 serum concentration, as well as the HDL2/HDL3 ratio, were determined in 359 individuals of both sexes, over 18 years of age. Values obtained were evaluated according to sociodemographic, clinical and biochemical characteristics. Results: Mean population age was 39.4 ± 15.2 years, and 51.5% were female. Differences in HDL-C subfraction levels were only observed in those subjects with low HDL-C levels. Women with hypertriglyceridemia showed significantly lower serum HDL3 and HDL2 concentrations than those with normal triglycerides (p=0.033), as well as a lower HDL3 level and HDL2 / HDL3 ratio in those with higher levels of ultra-sensitive C-reactive protein (us-CRP) (p<0.001). A significantly lower concentration of HDL2 was observed in men with some degree of hypertension (p=0.031), insulin resistance (p=0.050) and metabolic syndrome (p=0.003); while those with elevated us-CRP showed a lower concentration of HDL3 (p=0.011). Conclusion: HDL-C subfractions show varying clinical-epidemiological behavior in adults from Maracaibo. Lower serum levels are observed in men, differences only in those with low HDL-C; and no predominance of any subclass was observed according to sociodemographic, clinical and biochemical characteristics.

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Published

2020-08-25

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Section

Original Article

How to Cite

1.
Linares S, Bermúdez V, Salazar J, Nava M, Ortega Ángel, Olivar L, et al. Clinical-epidemiological analysis of HDL2 and HDL3 subfractions in adults from Maracaibo city, Venezuela. Rev Peru Med Exp Salud Publica [Internet]. 2020 Aug. 25 [cited 2025 Jun. 7];37(3):412-22. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/4787

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