Toxicity assessment of synthetic chalcones with antileishmanial potential in BALB/c MICE

Authors

  • Karina Cancino Laboratorio Mixto Internacional Andino-Amazónico de Química de la Vida IRD-UPCH, Universidad Peruana Cayetano Heredia, Lima, Perú. Bióloga http://orcid.org/0000-0002-6343-8785
  • Inés Castro Laboratorio Mixto Internacional Andino-Amazónico de Química de la Vida IRD-UPCH, Universidad Peruana Cayetano Heredia, Lima, Perú. licenciada en Farmacia y Bioquímica, magíster en Bioquímica y Biología Molecular http://orcid.org/0000-0003-4349-3477
  • Carlos Yauri Laboratorio Mixto Internacional Andino-Amazónico de Química de la Vida IRD-UPCH, Universidad Peruana Cayetano Heredia, Lima, Perú. bachiller en Farmacia y Bioquímica http://orcid.org/0000-0002-7393-6147
  • Valérie Jullian UMR 152 PHARMA-DEV, Université de Toulouse, IRD, Toulouse, Francia. química, PhD en Química Orgánica http://orcid.org/0000-0002-1675-9105
  • Jorge Arévalo Laboratorio de Biología Celular y Molecular de Tripanosomátidos, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú. biólogo, doctor en Ciencias https://orcid.org/0000-0003-3837-2849
  • Michel Sauvain UMR 152 PHARMA-DEV, Université de Toulouse, IRD, Toulouse, Francia. químico farmacéutico, PhD en Farmacoquímica http://orcid.org/0000-0003-3919-532X
  • Vanessa Adaui Laboratorio de Biología Celular y Molecular de Tripanosomátidos, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú. bióloga, PhD en Ciencias Biomédicas https://orcid.org/0000-0001-8516-006X
  • Denis Castillo Laboratorio Mixto Internacional Andino-Amazónico de Química de la Vida IRD-UPCH, Universidad Peruana Cayetano Heredia, Lima, Perú. biólogo, magíster en Bioquímica y Biología Molecular http://orcid.org/0000-0003-1010-2353

DOI:

https://doi.org/10.17843/rpmesp.2021.383.6937

Keywords:

Synthetic Chalcones, Drug Development, BALB/c Mice, Subchronic Toxicity, Median Lethal Dose

Abstract

Objective: To evaluate the toxicity of three synthetic chalcones administered intraperitoneally to BALB/c mice. Materials and methods: The median lethal dose (LD50) was estimated by Dixon’s Up-and-Down method. Subchronic toxicity of chalcones was evaluated at 20 and 40 mg/kg for 21 days. Behavioral, physiological, biochemical, biochemical and histological toxic effects were evaluated. Results: Chalcone 43 produced mucus in feces, visceral damage (liver) and alterations in organ coefficient (kidney, p = 0.037 and brain, p = 0.008) when compared to the control group. In addition, histological analysis showed that this chalcone produced edema, inflammation and necrosis in the organs that were evaluated, although there was no significant difference with the control. None of the biochemical parameters differed significantly between the treatment groups at 40 mg/kg dose and the control. Conclusions: The LD50 for all three chalcones was greater than 550 mg/kg of body weight. Chalcones 40 and 42 were found to be relatively non-toxic. Both can be considered safe for intraperitoneal application in BALB/c mice and, consequently, are potential candidates for use in the treatment of leishmaniasis.

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Published

2021-09-03

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Section

Original Article

How to Cite

1.
Cancino K, Castro I, Yauri C, Jullian V, Arévalo J, Sauvain M, et al. Toxicity assessment of synthetic chalcones with antileishmanial potential in BALB/c MICE. Rev Peru Med Exp Salud Publica [Internet]. 2021 Sep. 3 [cited 2024 Jun. 23];38(3):424-33. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/6937