Hypoglycemic effect of Moringa oleifera (moringa) compared with Smallanthus sonchifolius (yacon) on Rattus norvegicus with induced diabetes mellitus

Authors

  • Otto W. Vargas-Tineo Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Estudiante de Medicina Humana https://orcid.org/0000-0001-6242-7294
  • Dina M. Segura-Muñoz Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Estudiante de Medicina Humana https://orcid.org/0000-0002-4850-1854
  • Lizzie K. Becerra-Gutiérrez Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Dirección de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú. biólogo, doctor en Ciencias https://orcid.org/0000-0001-8243-7932
  • José P. Amado-Tineo Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. médico cirujano, especialista en Medicina Interna, doctor en Medicina https://orcid.org/0000-0002-3286-4650
  • Heber Silva-Díaz Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Dirección de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú. biólogo, doctor en Ciencias https://orcid.org/0000-0001-8263-9673

DOI:

https://doi.org/10.17843/rpmesp.2020.373.5275

Keywords:

Hypoglycemic Agents, Diabetes Mellitus, Moringa oleifera, Rats, Alloxan

Abstract

Objective: To compare the hypoglycemic effect of the aqueous extract of Moringa oleifera (moringa), Smallanthus sonchifolius (yacon) and metformin on Rattus norvegicus, albino variety, with induced diabetes mellitus. Materials and methods: Preclinical, experimental, controlled and randomized study. Diabetes was induced intraperitoneally with a dose of alloxan at 130 mg/kg. A total of 24 male Rattus norvegicus, albino variety, Holfzman strain (6 per group) were used. They were divided as follows: control group (no treatment), metformin group (14 mg/kg), M. oleifera group (200 mg/kg), and S. sonchifolius group (140 mg/kg), treatments were administered via orogastric tube for 15 days. Glycemia levels were determined using an Accu-Chek® Instant electronic glycometer (Roche). Results: Decreased glycemia was observed in the treatment groups: M. oleifera (p = 0.009), S. sonchifolius (p = 0.002) and metformin (p = 0.002), by 313 mg/dL, 281.5 mg/dL and 415 mg/dL, respectively. When comparing glycemia in the treated and control groups, no difference was observed (P > 0.05) at 24 hours and four days of treatment; while at the eighth (P < 0.05) and fifteenth day (P < 0.01) the treated groups had lower glycemia than the control group, but it was similar among them. Conclusion: The aqueous extract of S. sonchifolius, M. oleifera, and metformin presented similar hypoglycemic effect in experimental rats with induced diabetes.

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Author Biographies

  • Otto W. Vargas-Tineo, Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Estudiante de Medicina Humana

    Estudiante de Medicina Humana.

  • Dina M. Segura-Muñoz, Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Estudiante de Medicina Humana
    Estudiante de Medicina Humana.
  • Lizzie K. Becerra-Gutiérrez, Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Dirección de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú. biólogo, doctor en Ciencias
    Biólogo, Doctor en Ciencias.
  • José P. Amado-Tineo, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. médico cirujano, especialista en Medicina Interna, doctor en Medicina
    Médico internista. Doctor en Medicina.
  • Heber Silva-Díaz, Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú. Dirección de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú. biólogo, doctor en Ciencias
    Biólogo Microbiólogo, con maestría y doctorado en Ciencias. Docente de la Facultad de Medicina de la Universidad San Martín de Porres, filial Chiclayo y Biólogo en el Hospital Regional Lambayeque.

Published

2020-06-24

Issue

Section

Original Article

How to Cite

1.
Vargas-Tineo OW, Segura-Muñoz DM, Becerra-Gutiérrez LK, Amado-Tineo JP, Silva-Díaz H. Hypoglycemic effect of Moringa oleifera (moringa) compared with Smallanthus sonchifolius (yacon) on Rattus norvegicus with induced diabetes mellitus. Rev Peru Med Exp Salud Publica [Internet]. 2020 Jun. 24 [cited 2024 Mar. 4];37(3):478-84. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5275