Extended-spectrum beta-lactamase-producing enterobacterales carrying the mcr-1 gene in Lima, Peru

Authors

  • Katherine Yauri-Condor Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales - CITBM, Universidad Nacional Mayor de San Marcos, Lima, Perú. Tecnóloga/o médica/o https://orcid.org/0000-0003-2340-430X
  • Milagros Zavaleta Apestegui Centro de Investigaciones Tecnológicas Biomédicas y Medioambientales - UNMSM. bióloga molecular https://orcid.org/0000-0002-2743-9035
  • Carlos Raúl Sevilla-Andrade Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales - CITBM, Universidad Nacional Mayor de San Marcos, Lima, Perú. Instituto de Medicina Tropical «Daniel A. Carrión», Departamento Académico de Microbiología Médica, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. Tecnóloga/o médica/o https://orcid.org/0000-0001-9938-9922
  • Julia Piscoya Sara Instituto de Medicina Tropical «Daniel A. Carrión», Departamento Académico de Microbiología Médica, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú. médica/o cirujana/o; magíster en Epidemiología https://orcid.org/0000-0002-4048-1326
  • Claudia Villoslado Espinoza Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. médica/o cirujana/o especialista en Patología Clínica https://orcid.org/0000-0002-4915-9229
  • William Vicente Taboada Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú. Laboratorios Unilabs, Lima, Perú. médica/o cirujana/o especialista en Patología Clínica https://orcid.org/0000-0002-1366-3271
  • Edgar Gonzales-Escalante Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales - CITBM, Universidad Nacional Mayor de San Marcos, Lima, Perú. Laboratorio de Resistencia Bacteriana, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. Tecnóloga/o médica/o magíster en Microbiología https://orcid.org/0000-0002-3411-9021

DOI:

https://doi.org/10.17843/rpmesp.2020.374.5832

Keywords:

Enterobacteriaceae, beta-Lactamases, Colistin, Drug Resistance, Microbial

Abstract

We analyzed the presence of the mcr-1 gene in 165 extended-spectrum beta-lactamase-producing enterobacterales (ESBL-PE) obtained during 2017, from blood (40), urine (57), lower respiratory secretions (12) and rectal swabs (56) of patients hospitalized in the Instituto Nacional de Enfermedades Neoplásicas (Peru). Antimicrobial identification and susceptibility were determined by the Phoenix M50 automated system; colistin resistance by Colistin Agar-Spot (CAS); mrc-1 detection by colistin pre-diffusion and inhibition with EDTA test (CPD-E) and by polymerase chain reaction (PCR). We found that from the 165 ESBL-PE, 25 were positive for mcr-1 by the CPD-E method and confirmed by PCR. Colistin resistance was found in 20/165 by using the CAS method. Additionally, they showed resistance to fluoroquinolones and gentamicin, while remaining sensitive to amikacin; two isolates presented metallo-carbapenemases. Obtaining data on resistance to last-line antimicrobials (colistin) is crucial to establish measures for its control.

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Published

2020-11-05

Issue

Section

Brief Report

How to Cite

1.
Yauri-Condor K, Zavaleta Apestegui M, Sevilla-Andrade CR, Piscoya Sara J, Villoslado Espinoza C, Vicente Taboada W, et al. Extended-spectrum beta-lactamase-producing enterobacterales carrying the mcr-1 gene in Lima, Peru. Rev Peru Med Exp Salud Publica [Internet]. 2020 Nov. 5 [cited 2024 Mar. 19];37(4):711-5. Available from: https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/5832

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